The terpene that calms you down, gives you that relaxing feeling, Myrcene (β-myrcene).
It’s typically found in higher amounts in Cannabis indica strains and the effect can be felt in that comfortable lazy stoned effect. High myrcene strains are great for people that need to relax their muscles and a good choice for people with chronic pain and sleep problems. People that need to heal from serious illness often benefit from the sedative effect of myrcenes as well. Even though indica dominant strains othen have the highest amounts, there is also myrcene in sativa plants, just in lower concentrations.
Myrcene is not only found in Cannabis, but in many plants out there.
Myrcene is an acyclic monoterpene commonly found in nature in the essential oil of lemongrass (Cymbopogon citratus), hops (Humulus lupus), verbena (Verbena Officinalis), mango (Mangifera Indica), thyme (Thymus Vulgaris), bay (Laurus Nobilis) ,Cannabis and more.
B-myrcene is a natural compound with a great safety profile which could significantly improve immune functions, as well as decrease pain sensation in patients suffering from inflammatory, as well as chronic pain.
Given the known anti-inflammatory and antinociceptive effects of cannabis, it is important to discern the qualities that can provide the correct terpene synergy to manage different disorders such as osteoarthritis, neuropathic pain or dermatitis.
Although the mechanism of function of myrcene is not fully understood yet, it’s evident it has a promising role in the treatment of inflammation and pain.
Myrcene might help as a :
Analgesic – Relieves pain.
Antibacterial – Slows bacterial growth.
Anti-Diabetic – Helps mitigate the effects of diabetes.
Anti-inflammatory – Reduces inflammation systemically.
Anti-Insomnia – Aids with sleep.
Anti-Proliferative/Anti-Mutagenic – Inhibits cell mutation, including cancer cells.
Antipsychotic – Tranquilizing effects relieve symptoms of psychosis.
Antispasmodic – Suppresses muscle spasms.
As some cannabis strains more than others contain high levels of myrcene, to be on the safer side, it’s smart to choose indica dominant strains.
These strains are usually those with a more sedative effect and relaxing high.
Some great Indica strains for medical use are:
CBD Shark Shock -CBD Crew Seeds
Renè -House of the Great Gardener
Nordle ( Afgan Skunk ) - Mr.Nice Seeds
CBD Critcal Mass
Grows like a Sativa, flowers like an Indica. Big yielder, like it’s popular origins. Pay attention to supporting the plant during the final stage of flowering, use sticks to prevent branches from breaking or any system you prefer. She can become quite heavy at the top, but you will be happy for harvest!
CBD Shark Shock
CBD Shark, Mr.Nice Shark Shock crossed with a CBD rich variety to make a unique CBD plant for the Shark lovers. Short and strong plant. Fast flowering and a quite good yielding plant, especially if grown a little longer. Great calming effect, perfect for relaxing and recuperating!
CBD Skunk Haze
CBD Skunk Haze is a tall plant and quite self supporting, and quite easy to grow. It's a good hybrid and it's one of our most popular strains. Flowers tend to be large and airy, a bit more on the sativa side. Won 3rd place Sativa Cup at TreatingYourself Expo 2013, Ontario, Canada, competing with only high THC plants. Entered by a private grower.
CBD Crew has a world first in releasing this long awaited low THC and high CBD strain. While there are rumors of seed varieties originating out of hemp strains, the CBD Therapy is solely derived from recreational high THC cannabis strains and has taken some 4 years to try stabilize with the use of science. Still some work to do, CBD Crew is now stablizing the seeds even more.
We got the last seeds from 1st addition here and it can variate from 2:1 CBD:THC to 20:1 CBD:THC
CBD Crew is sold out! so this is the chance for you to get a hold of this amazing first edition of CBD Therapy, as second edition of CBD Therapy will not be released before April/mai 2017
CBD Nordle is a short and strong Christmas tree shape like plant. She produces dense and compact flowering clusters. One of the calmest most indica dominant strains we have, great for pain relief and muscle spasms. Nice tasty Indica with a relaxing effect!
CBD OG Kush
OG Kush is popular strain throughout the world for it's strong effects as a THC plant, but it changes dramatically as a CBD enriched version, CBD OG Kush. Still with the effects of THC, but with a freshness and clarity that is quite high for the normal Kush line.
Strong stemmed and quite self supporting. Gives large cola & beautiful buds. Super cropping recommended to get bigger yields. It can provide very low THC phenos, but mostly 1:1. Grows good both outdoors and indoors. Wonderful slightly uplifting effect, Yummy!
CBD Med Gom 1.0 Autoflower
CBD Med Gom is the result of a long research and development process carried out by Grass-O-Matic and CBD Crew to obtain a high grade medicinal cannabis strain with the advantages of automatic flowering.
CBD Sweet and Sour Widow
A CBD enriched White Widow strain, this grows vigorously during the vegetative stage and on flowering produces slightly airy flower clusters, which end highly resinous. The airy start to the bud formation makes this strain more suitable for humid areas where more compact plants would suffer from mould. This strain has a distinct but pleasant odour with a sour onion fragrance.
CBD Divine is a beautiful indica dominant regular strain. While the plant looks like a super skunk in appearance it has flavors ranging from citrus to fruit to berries and more.
CBD Pure Hazeling aka CBD PH is our strongest regular haze strain. With genetics that are the base of all major Haze strains and hybrids that the world has ever seen, this is a great plant for the devoted haze lover and grower.
CBD 3 Districts aka CBD 3D has its name from the wide spread genetic makeup covering 3 major districts, (Skunk, Afghan and Haze.) A complicated fragrance arises from an excellent Haze hybrid breeding true in CBD enrichment.
We at Shifa Shop look forward to even more studies on this terpene, its benefits and its benefits in combination with other terpenes and cannabinoids.
Until then, here are some studies to start off with if you are interested in learning more about Myrcene.
Myrcene and terpene regulation of TRPV1
Nociceptive Transient Receptor Potential channels such as TRPV1 are targets for treating pain.Both antagonism and agonism of TRP channels can promote analgesia, through inactivation andchronic desensitization. Since plant-derived mixtures of cannabinoids and theCannabiscompo-nent myrcene have been suggested as pain therapeutics, we screened terpenes found inCannabisfor activity at TRPV1. We used inducible expression of TRPV1 to examine TRPV1-dependency ofterpene-induced calcium flux responses. Terpenes contribute differentially to calcium fluxes viaTRPV1 induced byCannabis-mimetic cannabinoid/terpenoid mixtures. Myrcene dominates theTRPV1-mediated calcium responses seen with terpenoid mixtures. Myrcene-induced calcium influxis inhibited by the TRPV1 inhibitor capsazepine and Myrcene elicits TRPV1 currents in the whole-cell patch-clamp configuration. TRPV1 currents are highly sensitive to internal calcium. WhenMyrcene currents are evoked, they are distinct from capsaicin responses on the basis of Imaxandtheir lack of shift to a pore-dilated state. Myrcene pre-application and residency at TRPV1 appearsto negatively impact subsequent responses to TRPV1 ligands such as Cannabidiol, indicatingallosteric modulation and possible competition by Myrcene. Molecular docking studies suggesta non-covalent interaction site for Myrcene in TRPV1 and identifies key residues that form partiallyoverlapping Myrcene and Cannabidiol binding sites. We identify several non-Cannabisplant-derived sources of Myrcene and other compounds targeting nociceptive TRPs using a data miningapproach focused on analgesics suggested by non-Western Traditional Medical Systems. Thesedata establish TRPV1 as a target of Myrcene and suggest the therapeutic potential of analgesicformulations containing Myrcene.
Myrcene, an Aromatic Volatile Compound, Ameliorates Human Skin Extrinsic Aging via Regulation of MMPs Production-The American Journal of Chinese MedicineVol. 45, No. 05, pp. 1113-1124 (2017)
Abstract:Myrcene is an aromatic volatile compound that is commercially well-known as a flavor ingredient in the food industry and a fragrance in the soap and detergent industry. Given the worldwide interest in natural antiphotoaging products, we investigated the protective effects of myrcene in UVB-irradiated human dermal fibroblasts (NHDFs). NHDFs were subjected to 144mJ/cm2of UVB irradiation. The expression of intracellular reactive oxygen species (ROS), matrix metalloproteinase-1 (MMP-1), MMP-3, interleukin-6 (IL-6), transforming growth factor (TGF-β1) and type I procollagen were examined. We showed that myrcene decreased the production of ROS, MMP-1, MMP-3, and IL-6, and increased TGF-β1 and type I procollagen secretions. Furthermore, myrcene treatment (0.1–10μM) dramatically reduced the activation of MAPK-related signaling molecules such as p-ERK, p-p38, and p-JNK and AP-1 including p-c-Jun and p-c-Fos. Our data indicate that myrcene has a potential protective effect on UVB-induced human skin photoaging. Therefore, myrcene might have applications in the skincare industry.Single dose toxicity study of beta-myrcene, a natural analgesic substance.Braz J Med Biol Res. 1990;23(9):873-7.
Abstract:The present study was undertaken to provide data on acute toxicity of beta-myrcene, a peripheral analgesic substance found in the essential oils of several plants. Although myrcene has long been used in perfumes and as a food additive, there is almost no information on its toxicological hazards. The acute oral toxicity of myrcene was low in rodents, with approximate lethal doses (ALD) of 5.06 g/kg body weight for mice and greater than 11.39 g/kg body weight for rats. Necropsy data did not reveal any relevant alteration in rats but histopathology findings in mice suggested that the liver and stomach may be target organs for myrcene toxicity after oral administration. Myrcene is highly irritant to the peritoneum, and deaths after intraperitoneal injection of this monoterpene in rats (ALD 5.06 g/kg body weight) and in mice (ALD 2.25 g/kg body weight) were probably due to drug-induced chemical peritonitis.
*Terpenes are a diverse class of oils and organic compounds that are produced in many plants as secondary metabolites mainly for defence purposes, but also for favouring pollination.